The major histocompatibility system in the mouse. H-2 genes determine the major histocompatibility antigens on the surface of somatic cells and also the immune response Ir genes. The antigens in a given strain of mice are controlled by alleles within the H-2 locus. The H-2 system corresponds closely to the HLA system of humans, and much of our understanding of the latter was derived from studies in mice.

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