What is TUMOUR-SPECIFIC ANTIGEN?

Antigen present in tumour cells which is not expressed or only very minimally by their normal counterparts. Sometimes these are foetal antigens not normally expressed in the adult, and sometimes coded for by viral material incorporated into the host's genome. Significant in respect of the existence of specific immune responses to tumours which are present in tumour-bearing animals though insufficiently effective, and in respect of the use of radiolabelled or potentially immunotoxic antibodies targeted on tumour cells in vivo.


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