Synonym for the virus used in vaccine procedures to produce immunity to smallpox. Differs from cowpox and smallpox virus in minor antigens only and was probably derived originally from cowpox virus. The virus has proved very stable ie not liable to mutation and safe to use in humans, and produces long-lasting cell mediated immunity. Genes for other viral antigens have been introduced into vaccinia virus by recombinant DNA techniques with the intention that immunization with the recombinant strain shall produce protective immunity against other viruses also,

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