What is T6 MARKER CHROMOSOME?

A mouse chromosome originally derived from an irradiated male. It is about half the length of the shortest pair of autosomes and has a clearly detectable constriction near the centromere, so being easily recognizable in stained preparation of cells arrested in metaphase. The T6 chromosome has been introduced into an inbred strain of mice see recombinant inbred strain so as to replace the normal strain. The two strains are histocompatible so that the cells can be grafted from one to another without causing graft rejection. This has made it possible to follow the fate of particular cells or cell lines after transfer, and was the first technique to be used for this purpose. See panels on Chromosome and Immune response


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